About Centromere protein T
Centromere protein T (CENPT) is a protein
from Homo sapiens identified by UniProt accession
Q96BT3, 561 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Centromere protein T |
|---|
| UniProt accession | Q96BT3 |
|---|
| Gene | CENPT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 561 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- short stature and microcephaly with genital anomalies · score 0.45
- methylmalonic acidemia with homocystinuria, type cblX · score 0.27
- lymphocyte count · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
- BMI-adjusted waist circumference · score 0.05
- BMI-adjusted waist-hip ratio · score 0.05
- leukocyte count · score 0.05
- stem Cell Factor measurement · score 0.04
- high density lipoprotein cholesterol measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BT3-F1 | alphafold | PREDICTED | 56.14 | — |
Amino-acid sequence (561 residues)
MADHNPDSDS TPRTLLRRVL DTADPRTPRR PRSARAGARR ALLETASPRK LSGQTRTIAR GRSHGARSVG RSAHIQASGH LEEQTPRTLL KNILLTAPES SILMPESVVK PVPAPQAVQP SRQESSCGSL ELQLPELEPP TTLAPGLLAP GRRKQRLRLS VFQQGVDQGL SLSQEPQGNA DASSLTRSLN LTFATPLQPQ SVQRPGLARR PPARRAVDVG AFLRDLRDTS LAPPNIVLED TQPFSQPMVG SPNVYHSLPC TPHTGAEDAE QAAGRKTQSS GPGLQKNSPG KPAQFLAGEA EEVNAFALGF LSTSSGVSGE DEVEPLHDGV EEAEKKMEEE GVSVSEMEAT GAQGPSRVEE AEGHTEVTEA EGSQGTAEAD GPGASSGDED ASGRAASPES ASSTPESLQA RRHHQFLEPA PAPGAAVLSS EPAEPLLVRH PPRPRTTGPR PRQDPHKAGL SHYVKLFSFY AKMPMERKAL EMVEKCLDKY FQHLCDDLEV FAAHAGRKTV KPEDLELLMR RQGLVTDQVS LHVLVERHLP LEYRQLLIPC AYSGNSVFPA Q
Explore Centromere protein T with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets