Modulator of apoptosis 1 (MOAP1)

About Modulator of apoptosis 1

Modulator of apoptosis 1 (MOAP1) is a protein from Homo sapiens identified by UniProt accession Q96BY2, 351 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Modulator of apoptosis 1
UniProt accession	Q96BY2
Gene	MOAP1
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

neoplasm · score 0.08
cancer · score 0.07
neuroblastoma · score 0.03
hematopoietic and lymphoid system neoplasm · score 0.03
glioblastoma multiforme · score 0.03
colorectal carcinoma · score 0.02
non-small cell lung carcinoma · score 0.02
infection · score 0.02
infect · score 0.02
atypical teratoid rhabdoid tumor · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96BY2-F1	alphafold	PREDICTED	77.97	—

Amino-acid sequence (351 residues)

MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR LLGRMFRRDE NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDPDN TFLSRLNEFL AGEGMTVGEL SRALGHENGS LDPEQGMIPE MWAPMLAQAL EALQPALQCL KYKKLRVFSG RESPEPGEEE FGRWMFHTTQ MIKAWQVPDV EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV FGVTDNPREL QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQAILEGNF T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards