About Autophagy-related protein 2 homolog B
Autophagy-related protein 2 homolog B (ATG2B) is a protein
from Homo sapiens identified by UniProt accession
Q96BY7, 2078 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Autophagy-related protein 2 homolog B |
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| UniProt accession | Q96BY7 |
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| Gene | ATG2B |
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| Organism | Homo sapiens |
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| Length | 2078 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (60)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- gastrointestinal stromal tumor · score 0.06
- triple-negative breast cancer · score 0.04
- neoplasm · score 0.04
- Ataxia with vitamin E deficiency · score 0.03
- X-linked retinoschisis · score 0.03
- non-alcoholic steatohepatitis · score 0.03
- breast cancer · score 0.03
- ovarian carcinoma · score 0.02
- osteosarcoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BY7-F1 | alphafold | PREDICTED | 65.20 | — |
Amino-acid sequence (2078 residues)
MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP LDKWCLNEIL ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM VFRPRPRPAT GSEPMYWSSF MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL EKFAETIETV LRRVKVTFID TVLRIEHVPE NSKTGTALEI RIERTVYCDE TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS PVCSTAPVET EPKLSPSWNP KIIYEPHPQL TRNLPEIAPS DPVQIGRLIG RLELSLTLKQ NEVLPGAKLD VDGQIDSIHL LLSPRQVHLL LDMLAAIAGP ENSSKIGLAN KDRKNRPMQQ EDEYRIQMEL NRYYLRKDSL SVGVSSEQSF YETETARTPS SREEEVFFSM ADMDMSHSLS SLPPLGDPPN MDLELSLTST YTNTPAGSPL SATVLQPTWG EFLDHHKEQP VRGSTFPSNL VHPTPLQKTS LPSRSVSVDE SRPELIFRLA VGTFSISVLH IDPLSPPETS QNLNPLTPMA VAFFTCIEKI DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST DMSIGQMEFL ECLFPTDFHS VPPHYTELLT FHSKEETGSH SPVCLQLHYK HSENRGPQGN QARLSSVPHK AELQIKLNPV CCELDISIVD RLNSLLQPQK LATVEMMASH MYTSYNKHIS LHKAFTEVFL DDSHSPANCR ISVQVATPAL NLSVRFPIPD LRSDQERGPW FKKSLQKEIL YLAFTDLEFK TEFIGGSTPE QIKLELTFRE LIGSFQEEKG DPSIKFFHVS SGVDGDTTSS DDFDWPRIVL KINPPAMHSI LERIAAEEEE ENDGHYQEEE EGGAHSLKDV CDLRRPAPSP FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIYVTLPN KSFYEKLYNR IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK DSFSAFKSAV HYDEESGSEE ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS FLSVLLNINH GLIAVFTDVK QDNGDLLENK HGEFWLEFNS GSLFCVTKYE GFDDKHYICL HSSSFSLYHK GIVNGVILPT ETRLPSSTRP HWLEPTIYSS EEDGLSKTSS DGVGGDSLNM LSVAVKILSD KSESNTKEFL IAVGLKGATL QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPTSFTTFHV HLWSCALDYR PLYLPIRSLL TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI NLSRDYVRVM DMGLLELTIT AVKSDSDGEQ TEPRFELHCS SDVVHIRTCS DSCAALMNLI QYIASYGDLQ TPNKADMKPG AFQRRSKVDS SGRSSSRGPV LPEADQQMLR DLMSDAMEEI DMQQGTSSVK PQANGVLDEK SQIQEPCCSD LFLFPDESGN VSQESGPTYA SFSHHFISDA MTGVPTENDD FCILFAPKAA MQEKEEEPVI KIMVDDAIVI RDNYFSLPVN KTDTSKAPLH FPIPVIRYVV KEVSLVWHLY GGKDFGIVPP TSPAKSYISP HSSPSHTPTR HGRNTVCGGK GRNHDFLMEI QLSKVKFQHE VYPPCKPDCD SSLSEHPVSR QVFIVQDLEI RDRLATSQMN KFLYLYCSKE MPRKAHSNML TVKALHVCPE SGRSPQECCL RVSLMPLRLN IDQDALFFLK DFFTSLSAEV ELQMTPDPEV KKSPGADVTC SLPRHLSTSK EPNLVISFSG PKQPSQNDSA NSVEVVNGME EKNFSAEEAS FRDQPVFFRE FRFTSEVPIR LDYHGKHVSM DQGTLAGILI GLAQLNCSEL KLKRLSYRHG LLGVDKLFSY AITEWLNDIK KNQLPGILGG VGPMHSLVQL VQGLKDLVWL PIEQYRKDGR IVRGFQRGAA SFGTSTAMAA LELTNRMVQT IQAAAETAYD MVSPGTLSIE PKKTKRFPHH RLAHQPVDLR EGVAKAYSVV KEGITDTAQT IYETAAREHE SRGVTGAVGE VLRQIPPAVV KPLIVATEAT SNVLGGMRNQ IRPDVRQDES QKWRHGDD
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