About Store-operated calcium entry-associated regulatory factor
Store-operated calcium entry-associated regulatory factor (SARAF) is a protein
from Homo sapiens identified by UniProt accession
Q96BY9, 339 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Store-operated calcium entry-associated regulatory factor |
|---|
| UniProt accession | Q96BY9 |
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| Gene | SARAF |
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| Organism | Homo sapiens |
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| Length | 339 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- hair colour measurement · score 0.18
- balding measurement · score 0.18
- male infertility · score 0.17
- protein measurement · score 0.16
- mental or behavioural disorder · score 0.16
- hair shape measurement · score 0.15
- parental genotype effect measurement · score 0.13
- spontaneous preterm birth · score 0.13
- BMI-adjusted waist circumference · score 0.10
- FEV/FVC ratio · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BY9-F1 | alphafold | PREDICTED | 68.18 | — |
Amino-acid sequence (339 residues)
MAAACGPGAA GYCLLLGLHL FLLTAGPALG WNDPDRMLLR DVKALTLHYD RYTTSRRLDP IPQLKCVGGT AGCDSYTPKV IQCQNKGWDG YDVQWECKTD LDIAYKFGKT VVSCEGYESS EDQYVLRGSC GLEYNLDYTE LGLQKLKESG KQHGFASFSD YYYKWSSADS CNMSGLITIV VLLGIAFVVY KLFLSDGQYS PPPYSEYPPF SHRYQRFTNS AGPPPPGFKS EFTGPQNTGH GATSGFGSAF TGQQGYENSG PGFWTGLGTG GILGYLFGSN RAATPFSDSW YYPSYPPSYP GTWNRAYSPL HGGSGSYSVC SNSDTKTRTA SGYGGTRRR
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