Mitochondrial dynamics protein MID49 (MIEF2)

About Mitochondrial dynamics protein MID49

Mitochondrial dynamics protein MID49 (MIEF2) is a protein from Homo sapiens identified by UniProt accession Q96C03, 454 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Mitochondrial dynamics protein MID49
UniProt accession	Q96C03
Gene	MIEF2
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

combined oxidative phosphorylation deficiency 49 · score 0.45
cystatin C measurement · score 0.22
mitochondrial DNA measurement · score 0.20
hair colour measurement · score 0.17
blood protein measurement · score 0.14
serum alanine aminotransferase measurement · score 0.13
aspartate aminotransferase measurement · score 0.12
diastolic blood pressure · score 0.10
neoplasm · score 0.09
pachyonychia congenita · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96C03-F1	alphafold	PREDICTED	75.98	—

Amino-acid sequence (454 residues)

MAEFSQKRGK RRSDEGLGSM VDFLLANARL VLGVGGAAVL GIATLAVKRF IDRATSPRDE DDTKADSWKE LSLLKATPHL QPRPPPAALS QPVLPLAPSS SAPEGPAETD PEVTPQLSSP APLCLTLQER LLAFERDRVT IPAAQVALAK QLAGDIALEL QAYFRSKFPE LPFGAFVPGG PLYDGLQAGA ADHVRLLVPL VLEPGLWSLV PGVDTVARDP RCWAVRRTQL EFCPRGSSPW DRFLVGGYLS SRVLLELLRK ALAASVNWPA IGSLLGCLIR PSMASEELLL EVQHERLELT VAVLVAVPGV DADDRLLLAW PLEGLAGNLW LQDLYPVEAA RLRALDDHDA GTRRRLLLLL CAVCRGCSAL GQLGRGHLTQ VVLRLGEDNV DWTEEALGER FLQALELLIG SLEQASLPCH FNPSVNLFSS LREEEIDDIG YALYSGLQEP EGLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards