About ATP-dependent RNA helicase DHX58
ATP-dependent RNA helicase DHX58 (DHX58) is a protein
from Homo sapiens identified by UniProt accession
Q96C10, 678 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase DHX58 |
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| UniProt accession | Q96C10 |
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| Gene | DHX58 |
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| Organism | Homo sapiens |
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| Length | 678 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (157)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.27
- mean corpuscular volume · score 0.24
- genetic disorder · score 0.12
- mean corpuscular hemoglobin · score 0.10
- infect · score 0.08
- infection · score 0.08
- viral disease · score 0.08
- monocyte count · score 0.07
- IGF-1 measurement · score 0.06
- cystatin C measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96C10-F1 | alphafold | PREDICTED | 90.98 | — |
Amino-acid sequence (678 residues)
MELRSYQWEV IMPALEGKNI IIWLPTGAGK TRAAAYVAKR HLETVDGAKV VVLVNRVHLV TQHGEEFRRM LDGRWTVTTL SGDMGPRAGF GHLARCHDLL ICTAELLQMA LTSPEEEEHV ELTVFSLIVV DECHHTHKDT VYNVIMSQYL ELKLQRAQPL PQVLGLTASP GTGGASKLDG AINHVLQLCA NLDTWCIMSP QNCCPQLQEH SQQPCKQYNL CHRRSQDPFG DLLKKLMDQI HDHLEMPELS RKFGTQMYEQ QVVKLSEAAA LAGLQEQRVY ALHLRRYNDA LLIHDTVRAV DALAALQDFY HREHVTKTQI LCAERRLLAL FDDRKNELAH LATHGPENPK LEMLEKILQR QFSSSNSPRG IIFTRTRQSA HSLLLWLQQQ QGLQTVDIRA QLLIGAGNSS QSTHMTQRDQ QEVIQKFQDG TLNLLVATSV AEEGLDIPHC NVVVRYGLLT NEISMVQARG RARADQSVYA FVATEGSREL KRELINEALE TLMEQAVAAV QKMDQAEYQA KIRDLQQAAL TKRAAQAAQR ENQRQQFPVE HVQLLCINCM VAVGHGSDLR KVEGTHHVNV NPNFSNYYNV SRDPVVINKV FKDWKPGGVI SCRNCGEVWG LQMIYKSVKL PVLKVRSMLL ETPQGRIQAK KWSRVPFSVP DFDFLQHCAE NLSDLSLD
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