About Armadillo repeat-containing protein 5
Armadillo repeat-containing protein 5 (ARMC5) is a protein
from Homo sapiens identified by UniProt accession
Q96C12, 935 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Armadillo repeat-containing protein 5 |
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| UniProt accession | Q96C12 |
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| Gene | ARMC5 |
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| Organism | Homo sapiens |
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| Length | 935 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (72)
Diseases linked to this target (Open Targets).
- acth-independent macronodular adrenal hyperplasia 2 · score 0.80
- Cushing syndrome due to macronodular adrenal hyperplasia · score 0.44
- genetic disorder · score 0.19
- parental genotype effect measurement · score 0.11
- Glycosuria · score 0.11
- gestational blood glucose measurement · score 0.11
- fetal genotype effect measurement · score 0.08
- congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency · score 0.05
- pigmented nodular adrenocortical disease, primary, 3 · score 0.05
- glucocorticoid-remediable aldosteronism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96C12-F1 | alphafold | PREDICTED | 80.76 | — |
Amino-acid sequence (935 residues)
MAAAKPTLTD SLSFCLAQLA AAAGEALGGE KDPATNETPL SRALLALRTR HIKAAGGIER FRARGGLRPL LALLRRAAAA GSAPSQAGPG SAPSSAASGA SSPAPASGPA PSAVSSSSPT PPVRLRKTLD LALSILADCC TEGACRTEVR RLGGILPLVT ILQCMKTDSI QNRTARALGN LAMEPESCGD IHCAGAVPLL VESLTACQDS QCLQSVVRAL RNLADSPQHR LALAQQGAVR PLAELLATAP DAALTLALVR ALLELSRGCS RACAEQLSLG GGLGPLVSLA SHPKRAVREG TILILANLCA QGLIRPALGN AGGVEVLVDE LRQRRDPNGA SPTSQQPLVR AVCLLCREAI NRARLRDAGG LDLLMGLLRD PRASAWHPRI VAALVGFLYD TGALGRLQAL GLVPLLAGQL CGEAGEEEEE GREAASWDFP EERTPERAQG GSFRSLRSWL ISEGYATGPD DISPDWSPEQ CPPEPMEPAS PAPTPTSLRA PRTQRTPGRS PAAAIEEPWG REGPALLLLS RFSQAPDPSG ALVTGPALYG LLTYVTGAPG PPSPRALRIL SRLTCNPACL EAFVRSYGAA LLRAWLVLGV APDDWPAPRA RPTLHSRHRE LGERLLQNLT VQAESPFGVG ALTHLLLSGS PEDRVACALT LPFICRKPSL WRRLLLEQGG LRLLLAALTR PAPHPLFLFF AADSLSCLQD LVSPTVSPAV PQAVPMDLDS PSPCLYEPLL GPAPVPAPDL HFLLDSGLQL PAQRAASATA SPFFRALLSG SFAEAQMDLV PLRGLSPGAA WPVLHHLHGC RGCGAALGPV PPPGQPLLGS EAEEALEAAG RFLLPGLEEE LEEAVGRIHL GPQGGPESVG EVFRLGRPRL AAHCARWTLG SEQCPRKRGL ALVGLVEAAG EEAGPLTEAL LAVVMGIELG ARVPA
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