About EF-hand domain-containing protein D2
EF-hand domain-containing protein D2 (EFHD2) is a protein
from Homo sapiens identified by UniProt accession
Q96C19, 240 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | EF-hand domain-containing protein D2 |
|---|
| UniProt accession | Q96C19 |
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| Gene | EFHD2 |
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| Organism | Homo sapiens |
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| Length | 240 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (192)
Diseases linked to this target (Open Targets).
- cancer · score 0.10
- metabolite measurement · score 0.09
- neoplasm · score 0.08
- non-alcoholic steatohepatitis · score 0.07
- melanoma · score 0.07
- common variable immunodeficiency · score 0.07
- isolated agammaglobulinemia · score 0.07
- anxiety · score 0.06
- immunodeficiency 72 with autoinflammation · score 0.06
- BENTA disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96C19-F1 | alphafold | PREDICTED | 73.77 | — |
Amino-acid sequence (240 residues)
MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRRVF NPYTEFKEFS RKQIKDMEKM FKQYDAGRDG FIDLMELKLM MEKLGAPQTH LGLKNMIKEV DEDFDSKLSF REFLLIFRKA AAGELQEDSG LCVLARLSEI DVSSEGVKGA KSFFEAKVQA INVSSRFEEE IKAEQEERKK QAEEMKQRKA AFKELQSTFK
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