About Serine/threonine-protein kinase ULK4
Serine/threonine-protein kinase ULK4 (ULK4) is a protein
from Homo sapiens identified by UniProt accession
Q96C45, 1275 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase ULK4 |
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| UniProt accession | Q96C45 |
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| Gene | ULK4 |
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| Organism | Homo sapiens |
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| Length | 1275 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (146)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.48
- pulse pressure measurement · score 0.47
- systolic blood pressure · score 0.45
- hemoglobin measurement · score 0.44
- erythrocyte count · score 0.43
- multiple myeloma · score 0.39
- alcohol drinking · score 0.39
- hematocrit · score 0.37
- mean corpuscular volume · score 0.37
- red blood cell density measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96C45-F1 | alphafold | PREDICTED | 82.07 | — |
Amino-acid sequence (1275 residues)
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL APGSGSFADS AVAPLALEIL QAVGH
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