Endosome-associated-trafficking regulator 1 (ENTR1)

About Endosome-associated-trafficking regulator 1

Endosome-associated-trafficking regulator 1 (ENTR1) is a protein from Homo sapiens identified by UniProt accession Q96C92, 435 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Endosome-associated-trafficking regulator 1
UniProt accession	Q96C92
Gene	ENTR1
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

glucose measurement · score 0.15
Red cell distribution width · score 0.12
leukocyte count · score 0.10
Crohn's disease · score 0.08
low density lipoprotein cholesterol measurement · score 0.07
apolipoprotein B measurement · score 0.06
chronotype measurement · score 0.06
total cholesterol measurement · score 0.05
blood protein measurement · score 0.05
neutrophil percentage of leukocytes · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96C92-F1	alphafold	PREDICTED	64.61	—

Amino-acid sequence (435 residues)

MSGYQRRPGA TPLSRARSLA IPDAPAFYER RSCLPQLNCE RPHGRDLDSP FFGIRPAFMC YVPSPVLASV GDTDFGYGKG KCSKQSPSGA HGTHFGDDRF EDLEEANPFS FREFLKTKNL GLSKEDPASR IYAKEASRHS LGLDHNSPPS QTGGYGLEYQ QPFFEDPTGA GDLLDEEEDE DTGWSGAYLP SAIEQTHPER VPAGTSPCST YLSFFSTPSE LAGPESLPSW ALSDTDSRVS PASPAGSPSA DFAVHGESLG DRHLRTLQIS YDALKDENSK LRRKLNEVQS FSEAQTEMVR TLERKLEAKM IKEESDYHDL ESVVQQVEQN LELMTKRAVK AENHVVKLKQ EISLLQAQVS NFQRENEALR CGQGASLTVV KQNADVALQN LRVVMNSAQA SIKQLVSGAE TLNLVAEILK SIDRISEVKD EEEDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards