5-cytosine rRNA methyltransferase NSUN4 (NSUN4)

About 5-cytosine rRNA methyltransferase NSUN4

5-cytosine rRNA methyltransferase NSUN4 (NSUN4) is a protein from Homo sapiens identified by UniProt accession Q96CB9, 384 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	5-cytosine rRNA methyltransferase NSUN4
UniProt accession	Q96CB9
Gene	NSUN4
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
age at menopause · score 0.15
heel bone mineral density · score 0.06
acute lymphoblastic leukemia · score 0.04
serum metabolite measurement · score 0.03
N-acylethanolamine measurement · score 0.03
lung adenocarcinoma · score 0.03
neoplasm · score 0.02
cancer · score 0.02
hepatocellular carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CB9-F1	alphafold	PREDICTED	91.29	—

Amino-acid sequence (384 residues)

MAALTLRGVR ELLKRVDLAT VPRRHRYKKK WAATEPKFPA VRLALQNFDM TYSVQFGDLW PSIRVSLLSE QKYGALVNNF AAWDHVSAKL EQLSAKDFVN EAISHWELQS EGGQSAAPSP ASWACSPNLR CFTFDRGDIS RFPPARPGSL GVMEYYLMDA ASLLPVLALG LQPGDIVLDL CAAPGGKTLA LLQTGCCRNL AANDLSPSRI ARLQKILHSY VPEEIRDGNQ VRVTSWDGRK WGELEGDTYD RVLVDVPCTT DRHSLHEEEN NIFKRSRKKE RQILPVLQVQ LLAAGLLATK PGGHVVYSTC SLSHLQNEYV VQGAIELLAN QYSIQVQVED LTHFRRVFMD TFCFFSSCQV GELVIPNLMA NFGPMYFCKM RRLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards