About Inactive rhomboid protein 1
Inactive rhomboid protein 1 (RHBDF1) is a protein
from Homo sapiens identified by UniProt accession
Q96CC6, 855 residues long.
MolForge cross-references it against 0 known binders and
183 disease associations.
Target properties
| Protein name | Inactive rhomboid protein 1 |
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| UniProt accession | Q96CC6 |
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| Gene | RHBDF1 |
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| Organism | Homo sapiens |
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| Length | 855 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (183)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- mean corpuscular hemoglobin · score 0.27
- mean corpuscular volume · score 0.27
- Red cell distribution width · score 0.22
- blood protein measurement · score 0.22
- Wolff-Parkinson-White Syndrome · score 0.19
- Dilated cardiomyopathy · score 0.18
- dilated cardiomyopathy · score 0.18
- glioblastoma multiforme · score 0.12
- central nervous system cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CC6-F1 | alphafold | PREDICTED | 68.39 | — |
Amino-acid sequence (855 residues)
MSEARRDSTS SLQRKKPPWL KLDIPSAVPL TAEEPSFLQP LRRQAFLRSV SMPAETAHIS SPHHELRRPV LQRQTSITQT IRRGTADWFG VSKDSDSTQK WQRKSIRHCS QRYGKLKPQV LRELDLPSQD NVSLTSTETP PPLYVGPCQL GMQKIIDPLA RGRAFRVADD TAEGLSAPHT PVTPGAASLC SFSSSRSGFH RLPRRRKRES VAKMSFRAAA ALMKGRSVRD GTFRRAQRRS FTPASFLEED TTDFPDELDT SFFAREGILH EELSTYPDEV FESPSEAALK DWEKAPEQAD LTGGALDRSE LERSHLMLPL ERGWRKQKEG AAAPQPKVRL RQEVVSTAGP RRGQRIAVPV RKLFAREKRP YGLGMVGRLT NRTYRKRIDS FVKRQIEDMD DHRPFFTYWL TFVHSLVTIL AVCIYGIAPV GFSQHETVDS VLRNRGVYEN VKYVQQENFW IGPSSEALIH LGAKFSPCMR QDPQVHSFIR SAREREKHSA CCVRNDRSGC VQTSEEECSS TLAVWVKWPI HPSAPELAGH KRQFGSVCHQ DPRVCDEPSS EDPHEWPEDI TKWPICTKNS AGNHTNHPHM DCVITGRPCC IGTKGRCEIT SREYCDFMRG YFHEEATLCS QVHCMDDVCG LLPFLNPEVP DQFYRLWLSL FLHAGILHCL VSICFQMTVL RDLEKLAGWH RIAIIYLLSG VTGNLASAIF LPYRAEVGPA GSQFGILACL FVELFQSWQI LARPWRAFFK LLAVVLFLFT FGLLPWIDNF AHISGFISGL FLSFAFLPYI SFGKFDLYRK RCQIIIFQVV FLGLLAGLVV LFYVYPVRCE WCEFLTCIPF TDKFCEKYEL DAQLH
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