F-box/LRR-repeat protein 8 (FBXL8)

About F-box/LRR-repeat protein 8

F-box/LRR-repeat protein 8 (FBXL8) is a protein from Homo sapiens identified by UniProt accession Q96CD0, 374 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	F-box/LRR-repeat protein 8
UniProt accession	Q96CD0
Gene	FBXL8
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

early-onset zonular cataract · score 0.18
cataract 5 multiple types · score 0.18
mean corpuscular hemoglobin · score 0.08
neoplasm · score 0.08
myocardial infarction · score 0.07
cancer · score 0.07
deafness · score 0.05
mean corpuscular volume · score 0.05
neutropenia-monocytopenia-deafness syndrome · score 0.05
neutropenia, severe congenital, 2, autosomal dominant · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CD0-F1	alphafold	PREDICTED	91.56	—

Amino-acid sequence (374 residues)

MAEPGEGLPE EVLALIFRHL SLRDRAAAAR VCRAWAAAAT CSAVWHDTKI SCECELEGML PPYLSACLDH IHNLRLEFEP SRKPSRRAAI ELLMVLAGRA PGLRGLRLEC RGEKPLFDAG RDVLEAVHAV CGAASQLRHL DLRRLSFTLD DALVLQAARS CPELHSLFLD NSTLVGSVGP GSVLELLEAC PRLRALGLHL ASLSHAILEA LAAPDRAPFA LLALRCACPE DARASPLPNE AWVALRRRHP GLAVELELEP ALPAESVTRV LQPAVPVAAL RLNLSGDTVG PVRFAAHHYA ATLCALEVRA AASAELNAAL EELAARCAAL REVHCFCVVS HSVLDAFRAH CPRLRTYTLK LTREPHPWRP TLVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards