About Collagen triple helix repeat-containing protein 1
Collagen triple helix repeat-containing protein 1 (CTHRC1) is a protein
from Homo sapiens identified by UniProt accession
Q96CG8, 243 residues long.
MolForge cross-references it against 0 known binders and
264 disease associations.
Target properties
| Protein name | Collagen triple helix repeat-containing protein 1 |
|---|
| UniProt accession | Q96CG8 |
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| Gene | CTHRC1 |
|---|
| Organism | Homo sapiens |
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| Length | 243 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (264)
Diseases linked to this target (Open Targets).
- Barrett's esophagus · score 0.38
- esophageal adenocarcinoma · score 0.34
- erythrocyte count · score 0.17
- neoplasm · score 0.12
- cancer · score 0.11
- hepatocellular carcinoma · score 0.11
- non-small cell lung carcinoma · score 0.11
- lung adenocarcinoma · score 0.11
- esophageal squamous cell carcinoma · score 0.10
- melanoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CG8-F1 | alphafold | PREDICTED | 79.26 | — |
Amino-acid sequence (243 residues)
MRPQGPAASP QRLRGLLLLL LLQLPAPSSA SEIPKGKQKA QLRQREVVDL YNGMCLQGPA GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE LPK
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