About Pseudouridylate synthase RPUSD4, mitochondrial
Pseudouridylate synthase RPUSD4, mitochondrial (RPUSD4) is a protein
from Homo sapiens identified by UniProt accession
Q96CM3, 377 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Pseudouridylate synthase RPUSD4, mitochondrial |
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| UniProt accession | Q96CM3 |
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| Gene | RPUSD4 |
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| Organism | Homo sapiens |
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| Length | 377 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- body height · score 0.26
- neurodegenerative disease · score 0.24
- forced expiratory volume · score 0.16
- neutrophil count · score 0.15
- FEV/FVC ratio · score 0.15
- leukocyte count · score 0.14
- mean corpuscular hemoglobin · score 0.14
- body weight · score 0.13
- peak expiratory flow · score 0.11
- vital capacity · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CM3-F1 | alphafold | PREDICTED | 83.97 | — |
Amino-acid sequence (377 residues)
MAAPRWSASG PWIRGNGQGC GSLFTLVSKP FCAAAAASTA INAQRLAEKL RAQKREQDTK KEPVSTNAVQ RRVQEIVRFT RQLQRVHPNV LAKALTRGIL HQDKNLVVIN KPYGLPVHGG PGVQLCITDV LPILAKMLHG HKAEPLHLCH RLDKETTGVM VLAWDKDMAH QVQELFRTRQ VVKKYWAITV HVPMPSAGVV DIPIVEKEAQ GQQQHHKMTL SPSYRMDDGK MVKVRRSRNA QVAVTQYQVL SSTLSSALVE LQPITGIKHQ LRVHLSFGLD CPILGDHKYS DWNRLAPQKL SVGTLKKLGL EQSKARYIPL HLHARQLILP ALGSGKEELN LVCKLPRFFV HSLHRLRLEM PNEDQNENNE AKCLGAQ
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