About Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) is a protein
from Homo sapiens identified by UniProt accession
Q96CM8, 615 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Medium-chain acyl-CoA ligase ACSF2, mitochondrial |
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| UniProt accession | Q96CM8 |
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| Gene | ACSF2 |
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| Organism | Homo sapiens |
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| Length | 615 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.13
- hemoglobin D disease · score 0.05
- clear cell renal carcinoma · score 0.05
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
- hemoglobin E disease · score 0.04
- dominant beta-thalassemia · score 0.04
- Blackfan-Diamond anemia · score 0.04
- delta-beta-thalassemia · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
- alpha-thalassemia-myelodysplastic syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CM8-F1 | alphafold | PREDICTED | 89.14 | — |
Amino-acid sequence (615 residues)
MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSSREVDRM VSTPIGGLSY VQGCTKKHLN SKTVGQCLET TAQRVPEREA LVVLHEDVRL TFAQLKEEVD KAASGLLSIG LCKGDRLGMW GPNSYAWVLM QLATAQAGII LVSVNPAYQA MELEYVLKKV GCKALVFPKQ FKTQQYYNVL KQICPEVENA QPGALKSQRL PDLTTVISVD APLPGTLLLD EVVAAGSTRQ HLDQLQYNQQ FLSCHDPINI QFTSGTTGSP KGATLSHYNI VNNSNILGER LKLHEKTPEQ LRMILPNPLY HCLGSVAGTM MCLMYGATLI LASPIFNGKK ALEAISRERG TFLYGTPTMF VDILNQPDFS SYDISTMCGG VIAGSPAPPE LIRAIINKIN MKDLVVAYGT TENSPVTFAH FPEDTVEQKA ESVGRIMPHT EARIMNMEAG TLAKLNTPGE LCIRGYCVML GYWGEPQKTE EAVDQDKWYW TGDVATMNEQ GFCKIVGRSK DMIIRGGENI YPAELEDFFH THPKVQEVQV VGVKDDRMGE EICACIRLKD GEETTVEEIK AFCKGKISHF KIPKYIVFVT NYPLTISGKI QKFKLREQME RHLNL
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