FAS-associated factor 2 (FAF2)

About FAS-associated factor 2

FAS-associated factor 2 (FAF2) is a protein from Homo sapiens identified by UniProt accession Q96CS3, 445 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	FAS-associated factor 2
UniProt accession	Q96CS3
Gene	FAF2
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
PHF-tau measurement · score 0.22
serum albumin measurement · score 0.08
age at menopause · score 0.05
body height · score 0.04
venous thromboembolism · score 0.04
infection · score 0.02
infect · score 0.02
viral disease · score 0.01
hepatocellular carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CS3-F1	alphafold	PREDICTED	85.29	—

Amino-acid sequence (445 residues)

MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF IRPDPRSRVT DPVGDIVSFM HSFEEKYGRA HPVFYQGTYS QALNDAKREL RFLLVYLHGD DHQDSDEFCR NTLCAPEVIS LINTRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD RRMTVVGRLE GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS LRADQEKERK KREERERKRR KEEEVQQQKL AEERRRQNLQ EEKERKLECL PPEPSPDDPE SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK FQIEANFPRR VLPCIPSEEW PNPPTLQEAG LSHTEVLFVQ DLTDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards