Zinc finger protein 689 (ZNF689)

About Zinc finger protein 689

Zinc finger protein 689 (ZNF689) is a protein from Homo sapiens identified by UniProt accession Q96CS4, 500 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Zinc finger protein 689
UniProt accession	Q96CS4
Gene	ZNF689
Organism	Homo sapiens
Length	500 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.18
heel bone mineral density · score 0.15
high density lipoprotein cholesterol measurement · score 0.15
apolipoprotein A 1 measurement · score 0.15
self reported educational attainment · score 0.13
alkaline phosphatase measurement · score 0.11
bilirubin measurement · score 0.10
hepatocellular carcinoma · score 0.09
hypertension · score 0.08
testosterone measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CS4-F1	alphafold	PREDICTED	74.60	—

Amino-acid sequence (500 residues)

MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ RALYRDVMRE TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR GLTVQRKSRT RKKNGEKEVF PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI CPDCGCTFPD HQALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK APNCSPRSAI GGSSQRGNAH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards