Pleckstrin homology domain-containing family B…

About Pleckstrin homology domain-containing family B member 2

Pleckstrin homology domain-containing family B member 2 (PLEKHB2) is a protein from Homo sapiens identified by UniProt accession Q96CS7, 222 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Pleckstrin homology domain-containing family B member 2
UniProt accession	Q96CS7
Gene	PLEKHB2
Organism	Homo sapiens
Length	222 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

protein measurement · score 0.23
ovarian carcinoma · score 0.02
Abnormal sperm morphology · score 0.01
congenital heart disease · score 0.01
neoplasm · score 0.01
laryngeal squamous cell carcinoma · score 0.01
nonpapillary renal cell carcinoma · score 0.01
spindle cell hemangioma · score 0.01
Kidney Oncocytoma · score 0.01
acute myeloid leukemia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CS7-F1	alphafold	PREDICTED	68.82	—

Amino-acid sequence (222 residues)

MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT DETSVVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Pleckstrin homology domain-containing family B member 2 (PLEKHB2)