About Kelch-like protein 29
Kelch-like protein 29 (KLHL29) is a protein
from Homo sapiens identified by UniProt accession
Q96CT2, 875 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Kelch-like protein 29 |
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| UniProt accession | Q96CT2 |
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| Gene | KLHL29 |
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| Organism | Homo sapiens |
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| Length | 875 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (177)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.38
- appendicular lean mass · score 0.38
- mean platelet volume · score 0.37
- mean corpuscular hemoglobin concentration · score 0.33
- risk-taking behaviour · score 0.31
- neuroticism measurement · score 0.31
- neurofibrillary tangles measurement · score 0.31
- mathematical ability · score 0.30
- attention deficit hyperactivity disorder · score 0.30
- antisocial behaviour measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CT2-F1 | alphafold | PREDICTED | 70.08 | — |
Amino-acid sequence (875 residues)
MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR PGLLPLPVVP SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS KGDSQSQGLA TSIRWGQTPI NQSTPWDTDE PPSKQMRESD NPGTGPWVTT VAAGNQPTLI AHSYGVAQPP TFSPAVNVQA PVIGVTPSLP PHVGPQLPLM PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG VGQVARPGPT AVGNGHMAGP LLPPPPPAQP SATLPSGAPA TNGPPTTDSA HGLQMLRTIG VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC SLYFKDLIQR SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID SANAKTLLEA ASKFQFHTFC KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE LYHMAKAFAL QIFPEVAAQE EILSISKDDF IAYVSNDSLN TKAEELVYET VIKWIKKDPA TRTQYAAELL AVVRLPFIHP SYLLNVVDNE ELIKSSEACR DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL ADVWCYMSLL DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV ERYDTITNQW EAVAPLPKAV HSAAATVCGG KIYVFGGVNE AGRAAGVLQS YVPQTNTWSF IESPMIDNKY APAVTLNGFV FILGGAYARA TTIYDPEKGN IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM EAYEPTTNTW TLLPHMPCPV FRHGCVVIKK YIQSG
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