About Optineurin
Optineurin (OPTN) is a protein
from Homo sapiens identified by UniProt accession
Q96CV9, 577 residues long.
MolForge cross-references it against 0 known binders and
194 disease associations.
Target properties
| Protein name | Optineurin |
|---|
| UniProt accession | Q96CV9 |
|---|
| Gene | OPTN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 577 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (194)
Diseases linked to this target (Open Targets).
- familial amyotrophic lateral sclerosis · score 0.77
- open-angle glaucoma · score 0.77
- amyotrophic lateral sclerosis · score 0.70
- genetic disorder · score 0.50
- motor neuron disease · score 0.45
- osteitis deformans · score 0.40
- Amyotrophic lateral sclerosis · score 0.37
- leukocyte count · score 0.31
- frontotemporal dementia with motor neuron disease · score 0.27
- myeloid white cell count · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CV9-F1 | alphafold | PREDICTED | 77.26 | — |
Amino-acid sequence (577 residues)
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII
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