AP-2 complex subunit mu (AP2M1)

About AP-2 complex subunit mu

AP-2 complex subunit mu (AP2M1) is a protein from Homo sapiens identified by UniProt accession Q96CW1, 435 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	AP-2 complex subunit mu
UniProt accession	Q96CW1
Gene	AP2M1
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

intellectual developmental disorder 60 with seizures · score 0.65
neurodegenerative disease · score 0.57
HIV infection · score 0.56
Seizure · score 0.55
Intellectual disability · score 0.55
lysosomal storage disease · score 0.47
Alzheimer disease · score 0.47
Parkinson disease · score 0.46
Ataxia · score 0.46
Global developmental delay · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CW1-F1	alphafold	PREDICTED	89.17	—

Amino-acid sequence (435 residues)

MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QHQTKEEQSQ ITSQVTGQIG WRREGIKYRR NELFLDVLES VNLLMSPQGQ VLSAHVSGRV VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS IAIDDCTFHQ CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA IVWKIKRMAG MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK VRYLKVFEPK LNYSDHDVIK WVRYIGRSGI YETRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards