About Netrin-G2
Netrin-G2 (NTNG2) is a protein
from Homo sapiens identified by UniProt accession
Q96CW9, 530 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Netrin-G2 |
|---|
| UniProt accession | Q96CW9 |
|---|
| Gene | NTNG2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 530 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia · score 0.75
- Neurodevelopmental disorder · score 0.39
- self reported educational attainment · score 0.37
- complex neurodevelopmental disorder · score 0.37
- neurofibrillary tangles measurement · score 0.34
- Global developmental delay · score 0.34
- Generalized hypotonia · score 0.33
- protein measurement · score 0.33
- cholesteryl ester 16:0 measurement · score 0.32
- cognitive function measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CW9-F1 | alphafold | PREDICTED | 84.48 | — |
Amino-acid sequence (530 residues)
MLHLLALFLH CLPLASGDYD ICKSWVTTDE GPTWEFYACQ PKVMRLKDYV KVKVEPSGIT CGDPPERFCS HENPYLCSNE CDASNPDLAH PPRLMFDKEE EGLATYWQSI TWSRYPSPLE ANITLSWNKT VELTDDVVMT FEYGRPTVMV LEKSLDNGRT WQPYQFYAED CMEAFGMSAR RARDMSSSSA HRVLCTEEYS RWAGSKKEKH VRFEVRDRFA IFAGPDLRNM DNLYTRLESA KGLKEFFTLT DLRMRLLRPA LGGTYVQREN LYKYFYAISN IEVIGRCKCN LHANLCSMRE GSLQCECEHN TTGPDCGKCK KNFRTRSWRA GSYLPLPHGS PNACATAGSF GNCECYGHSN RCSYIDFLNV VTCVSCKHNT RGQHCQHCRL GYYRNGSAEL DDENVCIECN CNQIGSVHDR CNETGFCECR EGAAGPKCDD CLPTHYWRQG CYPNVCDDDQ LLCQNGGTCL QNQRCACPRG YTGVRCEQPR CDPADDDGGL DCDRAPGAAP RPATLLGCLL LLGLAARLGR
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