About BTB/POZ domain-containing protein KCTD12
BTB/POZ domain-containing protein KCTD12 (KCTD12) is a protein
from Homo sapiens identified by UniProt accession
Q96CX2, 325 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | BTB/POZ domain-containing protein KCTD12 |
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| UniProt accession | Q96CX2 |
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| Gene | KCTD12 |
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| Organism | Homo sapiens |
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| Length | 325 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (107)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.32
- ulcerative colitis · score 0.30
- neurofibrillary tangles measurement · score 0.24
- atopic march · score 0.17
- neoplasm · score 0.09
- gastrointestinal stromal tumor · score 0.09
- cancer · score 0.08
- breast cancer · score 0.07
- melanoma · score 0.07
- gut microbiome measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96CX2-F1 | alphafold | PREDICTED | 75.80 | — |
Amino-acid sequence (325 residues)
MALADSTRGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL WRMFTQQQPQ ELARDSKGRF FLDRDGFLFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF ELPELVRRLG APQQPGPGPP PSRRGVHKEG SLGDELLPLG YSEPEQQEGA SAGAPSPTLE LASRSPSGGA AGPLLTPSQS LDGSRRSGYI TIGYRGSYTI GRDAQADAKF RRVARITVCG KTSLAKEVFG DTLNESRDPD RPPERYTSRY YLKFNFLEQA FDKLSESGFH MVACSSTGTC AFASSTDQSE DKIWTSYTEY VFCRE
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