Hepatitis A virus cellular receptor 1 (HAVCR1)

About Hepatitis A virus cellular receptor 1

Hepatitis A virus cellular receptor 1 (HAVCR1) is a protein from Homo sapiens identified by UniProt accession Q96D42, 364 residues long. MolForge cross-references it against 0 known binders and 445 disease associations.

Target properties

Protein name	Hepatitis A virus cellular receptor 1
UniProt accession	Q96D42
Gene	HAVCR1
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (445)

Diseases linked to this target (Open Targets).

COVID-19 · score 0.48
blood protein measurement · score 0.47
kidney injury molecule 1 measurement · score 0.46
low density lipoprotein cholesterol measurement · score 0.44
neutrophil count · score 0.44
leukocyte count · score 0.40
myeloid white cell count · score 0.37
alcohol consumption measurement · score 0.36
alcohol drinking · score 0.32
T-cell immunoglobulin and mucin domain 1 measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96D42-F1	alphafold	PREDICTED	65.79	—

Amino-acid sequence (364 residues)

MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPMTT VPTTTVPTTM SIPTTTTVLT TMTVSTTTSV PTTTSIPTTT SVPVTTTVST FVPPMPLPRQ NHEPVATSPS SPQPAETHPT TLQGAIRREP TSSPLYSYTT DGNDTVTESS DGLWNNNQTQ LFLEHSLLTA NTTKGIYAGV CISVLVLLAL LGVIIAKKYF FKKEVQQLSV SFSSLQIKAL QNAVEKEVQA EDNIYIENSL YATD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards