About Atypical kinase COQ8B, mitochondrial
Atypical kinase COQ8B, mitochondrial (COQ8B) is a protein
from Homo sapiens identified by UniProt accession
Q96D53, 544 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Atypical kinase COQ8B, mitochondrial |
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| UniProt accession | Q96D53 |
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| Gene | COQ8B |
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| Organism | Homo sapiens |
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| Length | 544 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (58)
Diseases linked to this target (Open Targets).
- nephrotic syndrome · score 0.71
- mitochondrial disease · score 0.37
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.37
- genetic disorder · score 0.32
- Renal insufficiency · score 0.27
- leukocyte count · score 0.16
- nicotine metabolite ratio · score 0.12
- focal segmental glomerulosclerosis · score 0.12
- metabolite measurement · score 0.10
- mucocutaneous lymph node syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96D53-F1 | alphafold | PREDICTED | 76.08 | — |
Amino-acid sequence (544 residues)
MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL QSEGGSGLDS SPFLSEANAE RIVQTLCTVR GAALKVGQML SIQDNSFISP QLQHIFERVR QSADFMPRWQ MLRVLEEELG RDWQAKVASL EEVPFAAASI GQVHQGLLRD GTEVAVKIQY PGIAQSIQSD VQNLLAVLKM SAALPAGLFA EQSLQALQQE LAWECDYRRE AACAQNFRQL LANDPFFRVP AVVKELCTTR VLGMELAGGV PLDQCQGLSQ DLRNQICFQL LTLCLRELFE FRFMQTDPNW ANFLYDASSH QVTLLDFGAS REFGTEFTDH YIEVVKAAAD GDRDCVLQKS RDLKFLTGFE TKAFSDAHVE AVMILGEPFA TQGPYDFGSG ETARRIQDLI PVLLRHRLCP PPEETYALHR KLAGAFLACA HLRAHIACRD LFQDTYHRYW ASRQPDAATA GSLPTKGDSW VDPS
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