E3 ubiquitin-protein ligase RNF183 (RNF183)

About E3 ubiquitin-protein ligase RNF183

E3 ubiquitin-protein ligase RNF183 (RNF183) is a protein from Homo sapiens identified by UniProt accession Q96D59, 192 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF183
UniProt accession	Q96D59
Gene	RNF183
Organism	Homo sapiens
Length	192 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

appendicular lean mass · score 0.26
neutrophil count · score 0.15
body fat percentage · score 0.08
colorectal carcinoma · score 0.07
neoplasm · score 0.07
inflammatory bowel disease · score 0.04
ulcerative colitis · score 0.04
blood protein measurement · score 0.04
non-small cell lung carcinoma · score 0.04
colitis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96D59-F1	alphafold	PREDICTED	67.12	—

Amino-acid sequence (192 residues)

MAEQQGRELE AECPVCWNPF NNTFHTPKML DCCHSFCVEC LAHLSLVTPA RRRLLCPLCR QPTVLASGQP VTDLPTDTAM LALLRLEPHH VILEGHQLCL KDQPKSRYFL RQPQVYTLDL GPQPGGQTGP PPDTASATVS TPILIPSHHS LRECFRNPQF RIFAYLMAVI LSVTLLLIFS IFWTKQFLWG VG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards