Mitochondrial import inner membrane translocase…

About Mitochondrial import inner membrane translocase subunit TIM14

Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19) is a protein from Homo sapiens identified by UniProt accession Q96DA6, 116 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Mitochondrial import inner membrane translocase subunit TIM14
UniProt accession	Q96DA6
Gene	DNAJC19
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

3-methylglutaconic aciduria type 5 · score 0.78
Dilated cardiomyopathy with ataxia · score 0.71
3-methylglutaconic aciduria · score 0.56
genetic disorder · score 0.18
schizophrenia · score 0.18
self reported educational attainment · score 0.14
smoking status measurement · score 0.13
body mass index · score 0.11
autism spectrum disorder · score 0.10
intelligence · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96DA6-F1	alphafold	PREDICTED	87.50	—

Amino-acid sequence (116 residues)

MASTVVAVGL TIAAAGFAGR YVLQAMKHME PQVKQVFQSL PKSAFSGGYY RGGFEPKMTK REAALILGVS PTANKGKIRD AHRRIMLLNH PDKGGSPYIA AKINEAKDLL EGQAKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19)