About Transmembrane and coiled-coil domain-containing protein 6
Transmembrane and coiled-coil domain-containing protein 6 (TMCO6) is a protein
from Homo sapiens identified by UniProt accession
Q96DC7, 493 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Transmembrane and coiled-coil domain-containing protein 6 |
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| UniProt accession | Q96DC7 |
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| Gene | TMCO6 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- blood protein measurement · score 0.15
- monocyte count · score 0.08
- white matter microstructure measurement · score 0.06
- aspartate aminotransferase measurement · score 0.04
- total blood protein measurement · score 0.04
- forced expiratory volume · score 0.04
- thalamus volume · score 0.04
- body height · score 0.04
- systolic blood pressure · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96DC7-F1 | alphafold | PREDICTED | 87.34 | — |
Amino-acid sequence (493 residues)
MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP EEAGEGCVAA ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ QTFIRLEGSM RTLVGLLTSN QALLQLEAAR CLHELSHSEQ STVAEACLPA TSYLLTYLSS HSSDFIELCL YTLGNLIVES EAVRRQLLPQ GIVPALAACI QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH MLQMLQPGPK LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF QKQPSLLPEG LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM VLTVLCNVAE KGPAYCQRLW PGPLLPALLH TLAFSDTEVV GQSLELLHLL FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ DRVYALQQTA LQG
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