About Ubiquitin thioesterase OTUB2
Ubiquitin thioesterase OTUB2 (OTUB2) is a protein
from Homo sapiens identified by UniProt accession
Q96DC9, 234 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Ubiquitin thioesterase OTUB2 |
|---|
| UniProt accession | Q96DC9 |
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| Gene | OTUB2 |
|---|
| Organism | Homo sapiens |
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| Length | 234 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (54)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.19
- gastric adenocarcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.18
- neoplasm · score 0.10
- esophageal squamous cell carcinoma · score 0.09
- cancer · score 0.08
- platelet count · score 0.08
- sex hormone-binding globulin measurement · score 0.08
- non-small cell lung carcinoma · score 0.08
- gonorrhea · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96DC9-F1 | alphafold | PREDICTED | 94.20 | — |
Amino-acid sequence (234 residues)
MSETSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN CFYRALGYSY LESLLGKSRE IFKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK VFNDQSASDH IVQFLRLLTS AFIRNRADFF RHFIDEEMDI KDFCTHEVEP MATECDHIQI TALSQALSIA LQVEYVDEMD TALNHHVFPE AATPSVYLLY KTSHYNILYA ADKH
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