About Protein shisa-4
Protein shisa-4 (SHISA4) is a protein
from Homo sapiens identified by UniProt accession
Q96DD7, 197 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Protein shisa-4 |
|---|
| UniProt accession | Q96DD7 |
|---|
| Gene | SHISA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 197 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- body mass index · score 0.32
- depressive symptom measurement · score 0.30
- diastolic blood pressure · score 0.28
- tiredness measurement · score 0.27
- lean body mass · score 0.24
- neuroticism measurement · score 0.22
- daytime rest measurement · score 0.18
- body fat percentage · score 0.18
- gastroesophageal reflux disease · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96DD7-F1 | alphafold | PREDICTED | 69.24 | — |
Amino-acid sequence (197 residues)
MPPAGLRRAA PLTAIALLVL GAPLVLAGED CLWYLDRNGS WHPGFNCEFF TFCCGTCYHR YCCRDLTLLI TERQQKHCLA FSPKTIAGIA SAVILFVAVV ATTICCFLCS CCYLYRRRQQ LQSPFEGQEI PMTGIPVQPV YPYPQDPKAG PAPPQPGFIY PPSGPAPQYP LYPAGPPVYN PAAPPPYMPP QPSYPGA
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