RNA-binding protein Musashi homolog 2 (MSI2)

About RNA-binding protein Musashi homolog 2

RNA-binding protein Musashi homolog 2 (MSI2) is a protein from Homo sapiens identified by UniProt accession Q96DH6, 328 residues long. MolForge cross-references it against 0 known binders and 397 disease associations.

Target properties

Protein name	RNA-binding protein Musashi homolog 2
UniProt accession	Q96DH6
Gene	MSI2
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (397)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.49
eosinophil count · score 0.48
platelet count · score 0.48
neurodegenerative disease · score 0.44
platelet crit · score 0.43
neutrophil count · score 0.42
eosinophil percentage of leukocytes · score 0.42
leukocyte count · score 0.40
body mass index · score 0.40
myeloid white cell count · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96DH6-F1	alphafold	PREDICTED	66.11	—

Amino-acid sequence (328 residues)

MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS AASPQPGSGF GHGIAGPLIA TAFTNGYH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards