About Membrane-spanning 4-domains subfamily A member 6E
Membrane-spanning 4-domains subfamily A member 6E (MS4A6E) is a protein
from Homo sapiens identified by UniProt accession
Q96DS6, 147 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 6E |
|---|
| UniProt accession | Q96DS6 |
|---|
| Gene | MS4A6E |
|---|
| Organism | Homo sapiens |
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| Length | 147 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.35
- monocyte percentage of leukocytes · score 0.15
- soluble triggering receptor expressed on myeloid cells 2 measurement · score 0.14
- Alzheimer disease · score 0.11
- heel bone mineral density · score 0.11
- platelet count · score 0.10
- bone quantitative ultrasound measurement · score 0.09
- bone density · score 0.08
- ferritin measurement · score 0.08
- blood protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96DS6-F1 | alphafold | PREDICTED | 64.36 | — |
Amino-acid sequence (147 residues)
MTSQPISNET IIMLPSNVIN FSQAEKPEPT NQGQDSLKKR LQAKVKVIGV HSSLAGSILS ALSALVGFIL LSVNPAALNP ASLQCKLDEK DIPTRLLLSY DYHSPYTMDC HRAKASLAGT LSLMLVSTVL EFCLAVLTAV LQWKQTV
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