Cysteine protease ATG4C (ATG4C)

About Cysteine protease ATG4C

Cysteine protease ATG4C (ATG4C) is a protein from Homo sapiens identified by UniProt accession Q96DT6, 458 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Cysteine protease ATG4C
UniProt accession	Q96DT6
Gene	ATG4C
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.42
triglyceride measurement · score 0.26
total cholesterol measurement · score 0.26
breast adenocarcinoma · score 0.18
aspartate aminotransferase measurement · score 0.13
pancreatic adenocarcinoma · score 0.10
lymphatic system disease · score 0.09
heart failure · score 0.09
hypertension · score 0.09
response to xenobiotic stimulus · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96DT6-F1	alphafold	PREDICTED	79.78	—

Amino-acid sequence (458 residues)

MEATGTDEVD KLKTKFISAW NNMKYSWVLK TKTYFSRNSP VLLLGKCYHF KYEDEDKTLP AESGCTIEDH VIAGNVEEFR KDFISRIWLT YREEFPQIEG SALTTDCGWG CTLRTGQMLL AQGLILHFLG RAWTWPDALN IENSDSESWT SHTVKKFTAS FEASLSGERE FKTPTISLKE TIGKYSDDHE MRNEVYHRKI ISWFGDSPLA LFGLHQLIEY GKKSGKKAGD WYGPAVVAHI LRKAVEEARH PDLQGITIYV AQDCTVYNSD VIDKQSASMT SDNADDKAVI ILVPVRLGGE RTNTDYLEFV KGILSLEYCV GIIGGKPKQS YYFAGFQDDS LIYMDPHYCQ SFVDVSIKDF PLETFHCPSP KKMSFRKMDP SCTIGFYCRN VQDFKRASEE ITKMLKFSSK EKYPLFTFVN GHSRDYDFTS TTTNEEDLFS EDEKKQLKRF STEEFVLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards