About RING finger and SPRY domain-containing protein 1
RING finger and SPRY domain-containing protein 1 (RSPRY1) is a protein
from Homo sapiens identified by UniProt accession
Q96DX4, 576 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | RING finger and SPRY domain-containing protein 1 |
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| UniProt accession | Q96DX4 |
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| Gene | RSPRY1 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (12)
Diseases linked to this target (Open Targets).
- progressive spondyloepimetaphyseal dysplasia-short stature-short fourth metatarsals-intellectual disability syndrome · score 0.67
- mean corpuscular hemoglobin concentration · score 0.19
- genetic disorder · score 0.19
- apolipoprotein A 1 measurement · score 0.13
- blood urea nitrogen measurement · score 0.09
- serum gamma-glutamyl transferase measurement · score 0.08
- breast milk measurement · score 0.04
- skeletal dysplasia · score 0.01
- Skeletal dysplasia · score 0.01
- hepatitis C virus infection · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96DX4-F1 | alphafold | PREDICTED | 84.43 | — |
Amino-acid sequence (576 residues)
MIVFGWAVFL ASRSLGQGLL LTLEEHIAHF LGTGGAATTM GNSCICRDDS GTDDSVDTQQ QQAENSAVPT ADTRSQPRDP VRPPRRGRGP HEPRRKKQNV DGLVLDTLAV IRTLVDNDQE PPYSMITLHE MAETDEGWLD VVQSLIRVIP LEDPLGPAVI TLLLDECPLP TKDALQKLTE ILNLNGEVAC QDSSHPAKHR NTSAVLGCLA EKLAGPASIG LLSPGILEYL LQCLKLQSHP TVMLFALIAL EKFAQTSENK LTISESSISD RLVTLESWAN DPDYLKRQVG FCAQWSLDNL FLKEGRQLTY EKVNLSSIRA MLNSNDVSEY LKISPHGLEA RCDASSFESV RCTFCVDAGV WYYEVTVVTS GVMQIGWATR DSKFLNHEGY GIGDDEYSCA YDGCRQLIWY NARSKPHIHP CWKEGDTVGF LLDLNEKQMI FFLNGNQLPP EKQVFSSTVS GFFAAASFMS YQQCEFNFGA KPFKYPPSMK FSTFNDYAFL TAEEKIILPR HRRLALLKQV SIRENCCSLC CDEVADTQLK PCGHSDLCMD CALQLETCPL CRKEIVSRIR QISHIS
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