Endoplasmic reticulum lectin 1 (ERLEC1)

About Endoplasmic reticulum lectin 1

Endoplasmic reticulum lectin 1 (ERLEC1) is a protein from Homo sapiens identified by UniProt accession Q96DZ1, 483 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Endoplasmic reticulum lectin 1
UniProt accession	Q96DZ1
Gene	ERLEC1
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

holoprosencephaly · score 0.50
cystic fibrosis · score 0.46
reticulocyte count · score 0.40
Mandibular prognathia · score 0.37
mean corpuscular volume · score 0.33
lymphocyte count · score 0.33
pulse pressure measurement · score 0.31
Red cell distribution width · score 0.31
hemoglobin measurement · score 0.30
mean reticulocyte volume · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96DZ1-F1	alphafold	PREDICTED	72.96	—

Amino-acid sequence (483 residues)

MEEGGGGVRS LVPGGPVLLV LCGLLEASGG GRALPQLSDD IPFRVNWPGT EFSLPTTGVL YKEDNYVIMT TAHKEKYKCI LPLVTSGDEE EEKDYKGPNP RELLEPLFKQ SSCSYRIESY WTYEVCHGKH IRQYHEEKET GQKINIHEYY LGNMLAKNLL FEKEREAEEK EKSNEIPTKN IEGQMTPYYP VGMGNGTPCS LKQNRPRSST VMYICHPESK HEILSVAEVT TCEYEVVILT PLLCSHPKYR FRASPVNDIF CQSLPGSPFK PLTLRQLEQQ EEILRVPFRR NKEEDLQSTK EERFPAIHKS IAIGSQPVLT VGTTHISKLT DDQLIKEFLS GSYCFRGGVG WWKYEFCYGK HVHQYHEDKD SGKTSVVVGT WNQEEHIEWA KKNTARAYHL QDDGTQTVRM VSHFYGNGDI CDITDKPRQV TVKLKCKESD SPHAVTVYML EPHSCQYILG VESPVICKIL DTADENGLLS LPN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards