About PPP2R1A-PPP2R2A-interacting phosphatase regulator 1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR1) is a protein
from Homo sapiens identified by UniProt accession
Q96E09, 287 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 |
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| UniProt accession | Q96E09 |
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| Gene | PABIR1 |
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| Organism | Homo sapiens |
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| Length | 287 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.16
- creatinine measurement · score 0.15
- blood phosphate measurement · score 0.14
- cystatin C measurement · score 0.12
- urate measurement · score 0.11
- chronic kidney disease · score 0.11
- uric acid measurement · score 0.10
- blood urea nitrogen measurement · score 0.09
- calcium measurement · score 0.07
- lean body mass · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96E09-F1 | alphafold | PREDICTED | 59.43 | — |
Amino-acid sequence (287 residues)
MAQEKMELDL ELPPGTGGSP AEGGGSGGGG GLRRSNSAPL IHGLSDTSPV FQAEAPSARR NSTTFPSRHG LLLPASPVRM HSSRLHQIKQ EEGMDLINRE TVHEREVQTA MQISHSWEES FSLSDNDVEK SASPKRIDFI PVSPAPSPTR GIGKQCFSPS LQSFVSSNGL PPSPIPSPTT RFTTRRSQSP INCIRPSVLG PLKRKCEMET EYQPKRFFQG ITNMLSSDVA QLSDPGVCVS SDTLDGNSSS AGSSCNSPAK VSTTTDSPVS PAQAASPFIP LDELSSK
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