About Dehydrodolichyl diphosphate synthase complex subunit NUS1
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1) is a protein
from Homo sapiens identified by UniProt accession
Q96E22, 293 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Dehydrodolichyl diphosphate synthase complex subunit NUS1 |
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| UniProt accession | Q96E22 |
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| Gene | NUS1 |
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| Organism | Homo sapiens |
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| Length | 293 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation type I · score 0.73
- global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome · score 0.54
- type 2 diabetes mellitus · score 0.51
- genetic disorder · score 0.46
- retinitis pigmentosa · score 0.37
- intellectual disability, autosomal dominant 56 · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
- congenital disorder of glycosylation · score 0.34
- Drugs used in diabetes use measurement · score 0.32
- bilateral perisylvian polymicrogyria · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96E22-F1 | alphafold | PREDICTED | 82.02 | — |
Amino-acid sequence (293 residues)
MTGLYELVWR VLHALLCLHR TLTSWLRVRF GTWNWIWRRC CRAASAAVLA PLGFTLRKPP AVGRNRRHHR HPRGGSCLAA AHHRMRWRAD GRSLEKLPVH MGLVITEVEQ EPSFSDIASL VVWCMAVGIS YISVYDHQGI FKRNNSRLMD EILKQQQELL GLDCSKYSPE FANSNDKDDQ VLNCHLAVKV LSPEDGKADI VRAAQDFCQL VAQKQKRPTD LDVDTLASLL SSNGCPDPDL VLKFGPVDST LGFLPWHIRL TEIVSLPSHL NISYEDFFSA LRQYAACEQR LGK
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