About Transcription termination factor 3, mitochondrial
Transcription termination factor 3, mitochondrial (MTERF3) is a protein
from Homo sapiens identified by UniProt accession
Q96E29, 417 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Transcription termination factor 3, mitochondrial |
|---|
| UniProt accession | Q96E29 |
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| Gene | MTERF3 |
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| Organism | Homo sapiens |
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| Length | 417 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- cholelithiasis · score 0.10
- diffuse plaque measurement · score 0.08
- hepatocellular carcinoma · score 0.07
- gallstones · score 0.07
- type 2 diabetes mellitus · score 0.05
- peripheral arterial disease · score 0.05
- neoplasm · score 0.05
- protein measurement · score 0.04
- peak expiratory flow · score 0.03
- brain glioma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96E29-F1 | alphafold | PREDICTED | 75.79 | — |
Amino-acid sequence (417 residues)
MALSAQQIPR WFNSVKLRSL INAAQLTKRF TRPARTLLHG FSAQPQISSD NCFLQWGFKT YRTSSLWNSS QSTSSSSQEN NSAQSSLLPS MNEQSQKTQN ISSFDSELFL EELDELPPLS PMQPISEEEA IQIIADPPLP PASFTLRDYV DHSETLQKLV LLGVDLSKIE KHPEAANLLL RLDFEKDIKQ MLLFLKDVGI EDNQLGAFLT KNHAIFSEDL ENLKTRVAYL HSKNFSKADV AQMVRKAPFL LNFSVERLDN RLGFFQKELE LSVKKTRDLV VRLPRLLTGS LEPVKENMKV YRLELGFKHN EIQHMITRIP KMLTANKMKL TETFDFVHNV MSIPHHIIVK FPQVFNTRLF KVKERHLFLT YLGRAQYDPA KPNYISLDKL VSIPDEIFCE EIAKASVQDF EKFLKTL
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