About Metalloendopeptidase OMA1, mitochondrial
Metalloendopeptidase OMA1, mitochondrial (OMA1) is a protein
from Homo sapiens identified by UniProt accession
Q96E52, 524 residues long.
MolForge cross-references it against 0 known binders and
251 disease associations.
Target properties
| Protein name | Metalloendopeptidase OMA1, mitochondrial |
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| UniProt accession | Q96E52 |
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| Gene | OMA1 |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (251)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.25
- blood protein measurement · score 0.23
- breast adenocarcinoma · score 0.23
- adolescent idiopathic scoliosis · score 0.17
- esophageal cancer · score 0.15
- hepatocellular carcinoma · score 0.13
- neoplasm · score 0.09
- mathematical ability · score 0.08
- smoking status measurement · score 0.08
- antisocial behaviour measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96E52-F1 | alphafold | PREDICTED | 71.34 | — |
Amino-acid sequence (524 residues)
MSFICGLQSA ARNHVFFRFN SLSNWRKCNT LASTSRGCHQ VQVNHIVNKY QGLGVNQCDR WSFLPGNFHF YSTFNNKRTG GLSSTKSKEI WRITSKCTVW NDAFSRQLLI KEVTAVPSLS VLHPLSPASI RAIRNFHTSP RFQAAPVPLL LMILKPVQKL FAIIVGRGIR KWWQALPPNK KEVVKENIRK NKWKLFLGLS SFGLLFVVFY FTHLEVSPIT GRSKLLLLGK EQFRLLSELE YEAWMEEFKN DMLTEKDARY LAVKEVLCHL IECNKDVPGI SQINWVIHVV DSPIINAFVL PNGQMFVFTG FLNSVTDIHQ LSFLLGHEIA HAVLGHAAEK AGMVHLLDFL GMIFLTMIWA ICPRDSLALL CQWIQSKLQE YMFNRPYSRK LEAEADKIGL LLAAKACADI RASSVFWQQM EFVDSLHGQP KMPEWLSTHP SHGNRVEYLD RLIPQALKIR EMCNCPPLSN PDPRLLFKLS TKHFLEESEK EDLNITKKQK MDTLPIQKQE QIPLTYIVEK RTGS
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