About Leucine-rich repeat-containing protein 51
Leucine-rich repeat-containing protein 51 (LRRC51) is a protein
from Homo sapiens identified by UniProt accession
Q96E66, 192 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 51 |
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| UniProt accession | Q96E66 |
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| Gene | LRRC51 |
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| Organism | Homo sapiens |
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| Length | 192 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- deafness · score 0.42
- hearing loss, autosomal recessive · score 0.41
- autosomal recessive nonsyndromic hearing loss 63 · score 0.41
- Rare genetic deafness · score 0.27
- Asperger syndrome · score 0.08
- autism · score 0.07
- age-related macular degeneration · score 0.07
- X-linked retinal dysplasia · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- attention deficit hyperactivity disorder · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96E66-F1 | alphafold | PREDICTED | 91.53 | — |
Amino-acid sequence (192 residues)
MNKRDYMNTS VQEPPLDYSF RSIHVIQDLV NEEPRTGLRP LKRSKSGKSL TQSLWLNNNV LNDLRDFNQV ASQLLEHPEN LAWIDLSFND LTSIDPVLTT FFNLSVLYLH GNSIQRLGEV NKLAVLPRLR SLTLHGNPME EEKGYRQYVL CTLSRITTFD FSGVTKADRT TAEVWKRMNI KPKKAWTKQN TL
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