Elongator complex protein 4 (ELP4)

About Elongator complex protein 4

Elongator complex protein 4 (ELP4) is a protein from Homo sapiens identified by UniProt accession Q96EB1, 424 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Elongator complex protein 4
UniProt accession	Q96EB1
Gene	ELP4
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

aniridia · score 0.55
isolated aniridia · score 0.54
neurodegenerative disease · score 0.53
Peters anomaly · score 0.49
morning glory syndrome · score 0.44
coloboma of optic nerve · score 0.44
foveal hypoplasia 1 · score 0.41
autosomal dominant keratitis · score 0.41
Foveal hypoplasia - presenile cataract · score 0.41
WAGR syndrome · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EB1-F1	alphafold	PREDICTED	73.40	—

Amino-acid sequence (424 residues)

MAAVATCGSV AASTGSAVAT ASKSNVTSFQ RRGPRASVTN DSGPRLVSIA GTRPSVRNGQ LLVSTGLPAL DQLLGGGLAV GTVLLIEEDK YNIYSPLLFK YFLAEGIVNG HTLLVASAKE DPANILQELP APLLDDKCKK EFDEDVYNHK TPESNIKMKI AWRYQLLPKM EIGPVSSSRF GHYYDASKRM PQELIEASNW HGFFLPEKIS STLKVEPCSL TPGYTKLLQF IQNIIYEEGF DGSNPQKKQR NILRIGIQNL GSPLWGDDIC CAENGGNSHS LTKFLYVLRG LLRTSLSACI ITMPTHLIQN KAIIARVTTL SDVVVGLESF IGSERETNPL YKDYHGLIHI RQIPRLNNLI CDESDVKDLA FKLKRKLFTI ERLHLPPDLS DTVSRSSKMD LAESAKRLGP GCGMMAGGKK HLDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards