About Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 (MTMR8) is a protein
from Homo sapiens identified by UniProt accession
Q96EF0, 704 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 |
|---|
| UniProt accession | Q96EF0 |
|---|
| Gene | MTMR8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 704 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (11)
Diseases linked to this target (Open Targets).
- spinal muscular atrophy · score 0.14
- genetic disorder · score 0.12
- Kleine-Levin Syndrome · score 0.11
- testosterone measurement · score 0.02
- leiomyoma · score 0.01
- cancer · score 0.00
- Intellectual disability · score 0.00
- myxosarcoma · score 0.00
- multiple sclerosis · score 0.00
- ulcerative colitis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96EF0-F1 | alphafold | PREDICTED | 81.90 | — |
Amino-acid sequence (704 residues)
MDHITVPKVE NVKLVDRYVS KKPANGILYL TATHLIYVEA SGAARKETWI ALHHIATVEK LPITSLGCPL TLRCKNFRVA HFVLDSDLVC HEVYISLLKL SQPALPEDLY AFSYNPKSSK EMRESGWKLI DPISDFGRMG IPNRNWTITD ANRNYEICST YPPEIVVPKS VTLGTVVGSS KFRSKERVPV LSYLYKENNA AICRCSQPLS GFYTRCVDDE LLLEAISQTN PGSQFMYVVD TRPKLNAMAN RAAGKGYENE DNYANIRFRF MGIENIHVMR SSLQKLLEVC ELKTPTMSEF LSGLESSGWL RHIKAIMDAG IFITKAVKVE KASVLVHCSD GWDRTAQVCS VASILLDPFY RTFKGLMILI EKEWISMGHK FSQRCGHLDG DSKEVSPIFT QFLDCIWQLM EQFPCAFEFN ENFLLEIHDH VFSCQFGNFL GNCQKDREDL RVYEKTHSVW PFLVQRKPDF RNPLYKGFTM YGVLNPSTVP YNIQFWCGMY NRFDKGLQPK QSMLESLLEI KKQRAMLETD VHELEKKLKV RDEPPEEICT CSQLGNILSQ HLGSPLTNPL GFMGINGDLN TLMENGTLSR EGGLRAQMDQ VKSQGADLHH NCCEIVGSLR AINISGDVGI SEAMGISGDM CTFEATGFSK DLGICGAMDI SEATGISGNL GISEARGFSG DMGILGDTGI SKASTKEADY SKHQ
Explore Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets