Large ribosomal subunit protein mL53 (MRPL53)

About Large ribosomal subunit protein mL53

Large ribosomal subunit protein mL53 (MRPL53) is a protein from Homo sapiens identified by UniProt accession Q96EL3, 112 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Large ribosomal subunit protein mL53
UniProt accession	Q96EL3
Gene	MRPL53
Organism	Homo sapiens
Length	112 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
platelet count · score 0.20
serum urea measurement · score 0.14
body height · score 0.09
IGF-1 measurement · score 0.08
appendicular lean mass · score 0.08
platelet crit · score 0.06
Stress urinary incontinence · score 0.02
orofacial cleft · score 0.00
memory impairment · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EL3-F1	alphafold	PREDICTED	80.69	—

Amino-acid sequence (112 residues)

MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTAF ASHIRARDAA GSGDKPGADT GR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards