Trans-3-hydroxy-L-proline dehydratase (L3HYPDH)

About Trans-3-hydroxy-L-proline dehydratase

Trans-3-hydroxy-L-proline dehydratase (L3HYPDH) is a protein from Homo sapiens identified by UniProt accession Q96EM0, 354 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Trans-3-hydroxy-L-proline dehydratase
UniProt accession	Q96EM0
Gene	L3HYPDH
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

substance abuse · score 0.17
attention deficit hyperactivity disorder · score 0.17
antisocial behaviour measurement · score 0.17
monocyte count · score 0.12
body height · score 0.09
cortical surface area measurement · score 0.07
brain volume measurement · score 0.07
optic disc size measurement · score 0.04
neurofibrillary tangles measurement · score 0.03
lower face morphology measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EM0-F1	alphafold	PREDICTED	95.99	—

Amino-acid sequence (354 residues)

MESALAVPRL PPHDPGTPVL SVVDMHTGGE PLRIVLAGCP EVSGPTLLAK RRYMRQHLDH VRRRLMFEPR GHRDMYGAVL VPSELPDAHL GVLFLHNEGY SSMCGHAVLA LGRFALDFGL VPAPPAGTRE ARVNIHCPCG LVTAFVACED GRSHGPVRFH SVPAFVLATD LMVDVPGHGK VMVDIAYGGA FYAFVTAEKL GLDICSAKTR DLVDAASAVT EAVKAQFKIN HPDSEDLAFL YGTILTDGKD AYTKEPTTNI CVFADEQVDR SPTGSGVTAR IALQYHKGLL ELNQMRAFKS SATGSVFTGK AVREAKCGDF KAVIVEVSGQ AHYTGTASFI IEDDDPLRDG FLLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards