About Required for excision 1-B domain-containing protein
Required for excision 1-B domain-containing protein (REX1BD) is a protein
from Homo sapiens identified by UniProt accession
Q96EN9, 201 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Required for excision 1-B domain-containing protein |
|---|
| UniProt accession | Q96EN9 |
|---|
| Gene | REX1BD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 201 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
- Romano-Ward syndrome · score 0.07
- familial atrial fibrillation · score 0.07
- Brugada syndrome · score 0.07
- Griscelli syndrome type 3 · score 0.06
- Familial short QT syndrome · score 0.06
- Griscelli disease type 3 · score 0.05
- Griscelli disease · score 0.05
- hypertrophic cardiomyopathy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96EN9-F1 | alphafold | PREDICTED | 73.79 | — |
Amino-acid sequence (201 residues)
MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA ERAQGFRRLE EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY RSTVHGVTQA FAAASREVLA VEAELGGPRR QPLLAGHVRS LQELEQTRLG TVALLQLMET PELAGQEDAV RMQQLKMKVI KTMEAISEVL QDLRFDAESA E
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