About E3 ubiquitin-protein ligase CHFR
E3 ubiquitin-protein ligase CHFR (CHFR) is a protein
from Homo sapiens identified by UniProt accession
Q96EP1, 664 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase CHFR |
|---|
| UniProt accession | Q96EP1 |
|---|
| Gene | CHFR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 664 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.32
- mean corpuscular hemoglobin · score 0.27
- mean corpuscular volume · score 0.25
- body mass index · score 0.23
- body height · score 0.22
- lean body mass · score 0.21
- body weight · score 0.21
- neutrophil percentage of leukocytes · score 0.20
- lymphocyte percentage of leukocytes · score 0.20
- fat body mass · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96EP1-F1 | alphafold | PREDICTED | 72.00 | — |
Amino-acid sequence (664 residues)
MERPEEGKQS PPPQPWGRLL RLGAEEGEPH VLLRKREWTI GRRRGCDLSF PSNKLVSGDH CRIVVDEKSG QVTLEDTSTS GTVINKLKVV KKQTCPLQTG DVIYLVYRKN EPEHNVAYLY ESLSEKQGMT QESFEANKEN VFHGTKDTSG AGAGRGADPR VPPSSPATQV CFEEPQPSTS TSDLFPTASA SSTEPSPAGR ERSSSCGSGG GGISPKGSGP SVASDEVSSF ASALPDRKTA SFSSLEPQDQ EDLEPVKKKM RGDGDLDLNG QLLVAQPRRN AQTVHEDVRA AAGKPDKMEE TLTCIICQDL LHDCVSLQPC MHTFCAACYS GWMERSSLCP TCRCPVERIC KNHILNNLVE AYLIQHPDKS RSEEDVQSMD ARNKITQDML QPKVRRSFSD EEGSSEDLLE LSDVDSESSD ISQPYVVCRQ CPEYRRQAAQ PPHCPAPEGE PGAPQALGDA PSTSVSLTTA VQDYVCPLQG SHALCTCCFQ PMPDRRAERE QDPRVAPQQC AVCLQPFCHL YWGCTRTGCY GCLAPFCELN LGDKCLDGVL NNNSYESDIL KNYLATRGLT WKNMLTESLV ALQRGVFLLS DYRVTGDTVL CYCCGLRSFR ELTYQYRQNI PASELPVAVT SRPDCYWGRN CRTQVKAHHA MKFNHICEQT RFKN
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