Mitochondrial potassium channel (CCDC51)

About Mitochondrial potassium channel

Mitochondrial potassium channel (CCDC51) is a protein from Homo sapiens identified by UniProt accession Q96ER9, 411 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Mitochondrial potassium channel
UniProt accession	Q96ER9
Gene	CCDC51
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
platelet count · score 0.23
glomerular filtration rate · score 0.08
MODY · score 0.07
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
hemoglobin D disease · score 0.05
delta-beta-thalassemia · score 0.05
dominant beta-thalassemia · score 0.05
diabetes mellitus, permanent neonatal 4 · score 0.04
hemoglobin E-beta-thalassemia syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96ER9-F1	alphafold	PREDICTED	69.14	—

Amino-acid sequence (411 residues)

MMGRSPGFAM QHIVGVPHVL VRRGLLGRDL FMTRTLCSPG PSQPGEKRPE EVALGLHHRL PALGRALGHS IQQRATSTAK TWWDRYEEFV GLNEVREAQG KVTEAEKVFM VARGLVREAR EDLEVHQAKL KEVRDRLDRV SREDSQYLEL ATLEHRMLQE EKRLRTAYLR AEDSEREKFS LFSAAVRESH EKERTRAERT KNWSLIGSVL GALIGVAGST YVNRVRLQEL KALLLEAQKG PVSLQEAIRE QASSYSRQQR DLHNLMVDLR GLVHAAGPGQ DSGSQAGSPP TRDRDVDVLS AALKEQLSHS RQVHSCLEGL REQLDGLEKT CSQMAGVVQL VKSAAHPGLV EPADGAMPSF LLEQGSMILA LSDTEQRLEA QVNRNTIYST LVTCVTFVAT LPVLYMLFKA S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards