RNA-binding protein 33 (RBM33)

About RNA-binding protein 33

RNA-binding protein 33 (RBM33) is a protein from Homo sapiens identified by UniProt accession Q96EV2, 1170 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	RNA-binding protein 33
UniProt accession	Q96EV2
Gene	RBM33
Organism	Homo sapiens
Length	1170 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
self reported educational attainment · score 0.40
systolic blood pressure · score 0.38
pulse pressure measurement · score 0.29
neuroimaging measurement · score 0.15
brain measurement · score 0.14
brain volume measurement · score 0.14
heel bone mineral density · score 0.09
cortical surface area measurement · score 0.08
cortical thickness · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EV2-F1	alphafold	PREDICTED	46.56	—

Amino-acid sequence (1170 residues)

MAAALGASGG AGAGDDDFDQ FDKPGAERSW RRRAADEDWD SELEDDLLGE DLLSGKKNQS DLSDEELNDD LLQSDNEDEE NFSSQGVTIS LNATSGMVTS FELSDNTNDQ SGEQESEYEQ EQGEDELVYH KSDGSELYTQ EYPEEGQYEG HEAELTEDQI EYVEEPEEEQ LYTDEVLDIE INEPLDEFTG GMETLELQKD IKEESDEEEE DDEESGRLRF KTERKEGTII RLSDVTRERR NIPETLELSA EAKAALLEFE ERERQHKQGR YSSRRGGRRG GPLMCRGVGD QRRESTERGR MKDHRPALLP TQPPVVPQAP PPPPPPPQQQ PIRSLFQPQP LQPLLPVQHP HHPSPPQGMH MPPQLETPRM MMTPPPVTPQ QPKNIHINPH FKGTVVTPVQ VPLLPVPSQP RPAVGPQRFP GPPEFPQHTP GPVPNSFSQP PRLPLQDQWR APPPPQDRDP FFLGVSGEPR FPSHLFLEQR SPPPPPPPPT LLNSSHPVPT QSPLPFTQPG PAFNQQGQQP VFPRERPVRP ALQPPGPVGI LHFSQPGSAT TRPFIPPRQP FLPGPGQPFL PTHTQPNLQG PLHPPLPPPH QPQPQQPQQQ PPPQHQPPHQ PPHQPPPQHQ PPPQHPPQHP PQHQHHHHHH HLSVPPPPLM PMSQPQFRPH VQTAQPQASS SRMQCPQRQG LRHNTTSQNV SKRPMQQMQP TAPRNSNLRE LPIAPSHVIE MSSSRCSATP SAQVKPIVSA SPPSRAVAGS RSSQGKTEVK VKPASPVAQP KEEAKTETEF PDEDEETRLY RLKIEEQKRL REEILKQKEL RRQQQAGARK KELLERLAQQ QQQLYAPPPP AEQEEQALSP SPTNGNPLLP FPGAQVRQNV KNRLLVKNQD VSISNVQPKT SNFVPSSANM QYQGQQMKAL KHLRQTRTVP QSQTQPLHKV LPIKPADVEE PAVPQTPRVA SIQGRPQDTK PGVKRTVTHR TNSGGGDGPH ISSKVRVIKL SGGGGESDGF FHPEGQPQRL PQPPEVGPQP ARKVTLTRGG LQQPPHLPAG PHAHSPVPPG IKSIQGIHPA KKAIMHGRGR GVAGPMGRGR LMPNKQNLRV VECKPQPCVV SVEGLSSSTT DAQLKSLLMS VGPIQSLQML PQQRKAIAKF KEPAHALAFQ QKFHRHMIDL SHINVALIVE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards