Small integral membrane protein 12 (SMIM12)

About Small integral membrane protein 12

Small integral membrane protein 12 (SMIM12) is a protein from Homo sapiens identified by UniProt accession Q96EX1, 92 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Small integral membrane protein 12
UniProt accession	Q96EX1
Gene	SMIM12
Organism	Homo sapiens
Length	92 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

platelet component distribution width · score 0.33
neurofibrillary tangles measurement · score 0.28
platelet count · score 0.28
myeloid white cell count · score 0.27
monocyte count · score 0.27
platelet crit · score 0.27
mean corpuscular volume · score 0.24
viral load · score 0.14
intraocular pressure measurement · score 0.13
alcohol consumption measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EX1-F1	alphafold	PREDICTED	77.85	—

Amino-acid sequence (92 residues)

MWPVFWTVVR TYAPYVTFPV AFVVGAVGYH LEWFIRGKDP QPVEEEKSIS ERREDRKLDE LLGKDHTQVV SLKDKLEFAP KAVLNRNRPE KN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards